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  欢迎光临英国Farfield公司中国代表处网站  
 

英国Farfield公司致力于为全球的生物学蛋白检测、表面科学及纳米科技领域提供创新的科学分析仪器,使用户在分子甚至原子的层面上理解物质之间的相互作用及作用期间的实时变化,给出相应的动力学及热力学参数,如:分子直径、厚度、密度、表面浓度及固-液、液-液界面薄膜实时反应和变化。公司核心的DPI (Dual Polarization Interferometry)技术及基于DPI技术的AnaLight系列双偏振极化干涉测量分析系统应用范围包括:
蛋白质科学研究应用:
1、定量测量蛋白质构象变化分析
2、蛋白质聚集、折叠分析(Alzheimer's等神经退行性疾病)
3、蛋白质与小分子(如药物小分子、金属离子等)间相互作用
4、膜、脂和蛋白质间相互作用
5、蛋白质和多肽等大分子间相互作过程分析、药物筛选
6、抗原-抗体;受体-配体
表面分析应用:
1、表活剂、聚合物等界面相互作用研究
2、界面物理化学、界面科学、洗脱研究
3、胶体表面化学中两亲分子有序组合体和分子自组装研究
4、生物材料表面化学(如隐形眼镜、体内植入体等)
  DPI为定量测量技术,尤其在蛋白质结构及蛋白质与小分子之间的相互作用的研究领域突破目前所有其它即时测量分子动力学技术的瓶颈。该技术在上述领域应用广泛并发表大量文献。被称做”分子显微镜“的DPI仪器是目前测量分子相互作用时结构及构象变化最灵敏的技术平台。由于DPI技术具有极高的灵敏度,能够测量分子之间相互作用时分子层中<0.1A厚度及<0.1pg/平方毫米密度的实时的变化(如分子量为100000Da的蛋白和分子量为50Da的小分子相互作用,感应灵敏度<5Da),并给出动力学及热力学变化曲线,因此DPI技术提供的数据与核磁共振(NMR)、X射线晶体衍射(X-ray Crystallograph)及中子反射等相比更具有优越性, 是其他生物传感技术如SPR、QCM等无法比拟的。
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DPI双偏振极化干涉测量分析仪文献目录: DPI双偏振极化干涉测量分析仪用户期刊:
2007年6月前     第一期 第三期 第五期
      第二期 第四期 第六期
      第七期 第八期 第九期
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DPI 最新信息:
Pre-Adsorption of Amphiphilic Polymers on Synthetic Surfaces for Biofouling Retardation...details
2006年11月14日Farfield CEO Gerry博士在北京做DPI在蛋白质结构和功能研究应用报告...details
IAsys系列表面等离子共振(SPR)仪器招各地代理......details
DPI技术用于Alzheimer's阿尔茨海默病研究获得突破进展......details
2006年7月10日,英国Farfield公司收购美国热电(Thermo)的IAsys(SPR)产品生产业务......details
Farfield公司DPI技术经过英国国家物理实验室认证......details
Farfield公司启动DPI技术用于蛋白质结晶早期检测......details
 
 
 
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